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In conclusion, both SGLT2-i and GLP1-RA seem to have several effects on RAAS, though additional studies are needed to clarify this relationship

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for type 2 diabetes mellitus and weight management

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A recent study demonstrated that amphiphile modification of G12D and G12R mutant KRAS (mKRAS) peptides (Amph-Peptides-2P) in combination with CpG oligonucleotide adjuvant (Amph-CpG-7909) enhanced the delivery of cancer vaccines to lymph nodes and promoted anti-tumor immune responses in pancreatic and colorectal cancer (38)