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To gain an overview of the overall difference in sgRNA abundance, we performed principal component analysis, which revealed reproducible segregation of the treated replicates from the input plasmid library stock and the non-treated cells, assuring the overall quality and reproducibility of the experiments (Fig S2A, Table S2)

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Its skin-whitening properties are rooted in its ability to inhibit the production of melanin, the pigment responsible for skin colour

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