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Description

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

However, native GLP-1 has a very short half-life only about 12 minutes because it is rapidly degraded by the enzyme DPP-4 (dipeptidyl peptidase-4)

6,30 Pregnancy: All DPP-4 inhibitors are considered Pregnancy Category B because safety in humans has not been proven in adequate and well-controlled studies