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Comorbid conditions such as ADHD, depression, and anxiety disorder frequently co-occur in individuals with ASD in clinical settings [65, 66], and their inclusion in the analysis would yield results more reflective of real-world conditions for these individuals

Nat Commun 11:5564

To generate endothelial cell-specific Pcsk5 knockout mice on a C57BL/6 background ( Pcsk5 ECKO ), Pcsk5 loxP mice were crossed with the Cdh5-2A-CreERT2 line