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Pivotal Phase 2 Trial Results The pivotal Phase 2 trial, published by Jastreboff and colleagues in the New England Journal of Medicine in August 2023, enrolled 338 adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity but without diabetes

Over-the-counter options like ginger and vitamin B6 are safe and may help reduce nausea

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For people who cannot tolerate GLP-1 medications or prefer to avoid pharmaceutical interventions, the gentler side effect profile of supplements represents a meaningful advantage even if the results are more modest