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Diagnosed microvascular complications were observed in 47.1% for retinopathy, 51.4% for neuropathy, and 33.5% for nephropathy

Elevated TSH further augments TLR4/NF-B signaling, reinforcing a vicious cycle between inflammation and insulin resistance (73, 81, 82)

Representative search terms included: Rhodiola rosea OR Rhodiola , Ginkgo biloba , Withania somnifera OR Ashwagandha in combination with depression , antidepressant , monoaminergic neurotransmission , BDNF , neuroplasticity , HPA axis , neuroinflammation , oxidative stress , mitochondrial dysfunction , and clinical trial . Boolean operators and database-specific filters were applied where appropriate to optimize sensitivity and specificity

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