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The two cysteines in this motif catalyze glutathione (GSH)-dependent thiol-disulfide exchange reactions, i.e., the reduction of protein disulfides and, with high specificity, reversible (de-)glutathionylation [19] Oxidized Grxs are reduced by GSH, the resulting GSH disulfide (GSSG) by glutathione reductase (GR) using NADPH as electron source [20]

A: Yes, according to FDA prescribing information, all GLP-1 medications available through Ro are administered as subcutaneous (under-skin) injections: Frequency : Once weekly (same day each week) Injection sites : Abdomen, thigh, or upper arm (rotate sites) Needle size : Very small (similar to insulin needles) Administration time : Less than 1 minute Most members report that injection anxiety diminishes significantly after first few doses