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This review summarizes the molecular characteristics and antioxidant functions of GPX4, evaluates experimental evidence linking GPX4 and ferroptosis in OA, outlines upstream and downstream molecular mechanisms regulating GPX4, and summarizes therapeutic strategies targeting GPX4, including pharmacological, gene, and combination therapies

This article covers the biological mechanisms at work, the clinical evidence supporting (or questioning) dual therapy, what monitoring your prescriber should implement, and the scenarios where combining sermorelin with semaglutide makes sense versus where it's unnecessary complexity