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The trial is strengthened by its long duration, large sample size, stringent criteria for prediabetes, and rigorous assessment of diabetes onset using American Diabetes Association standards

The formulations of the basal diet and wheat flour-dough particle are listed in Table 1

15 The SFRP2/DPP4 fibroblast subpopulation serves as the progenitor for fibrogenic fibroblasts in SSc skin, and DPP4-induced NF-kB and SMAD signaling via PAR2 activation leads to dermal fibroblast activation