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Chelating catalytic metals-promoters of reactive oxidative species (ROS), such as Fe and Cu

A recent study demonstrated that primary GO orbital fibroblasts exhibited stronger resistance to ferroptosis induced by cystine deprivation or erastin compared to control fibroblasts, and seleniumwhich enhances GPX4 activityprotected control fibroblasts from ferroptotic cell death (140)

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Coordinates 4G73 were chosen to position the NADH, FAD, and vitamin K due to the higher sequence identity in the crystal structure of Ndi1 to FSP1 (29%), resolution limit (2.5 ) and these coordinates have both cofactors (NADH and FAD) and the substrate quinone bound