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The buffering genetic interaction revealed from our CRISPR screen 13 allowed further extending the finding by demonstrating a functional coordination of mitochondrial glutathione uptake (mediated by SLC25A39) and mitochondrial iron import (mediated by SLC25A37) in supporting OXPHOS

Valko MM, Morris H (2005) Cronin MT (2005) Metals, toxicity and oxidative stress

Luciferase activity from transfection (-GnHCl), which measures RNA replication, was comparable in the cell lysates co-infected with CAV20-wt or CAV20-BSOr viruses (Figure 5C), confirming our preliminary finding that GSH-depletion has no inhibitory effect on RNA replication (Figure 5B)