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The IGF system plays critical roles in cellular growth, metabolism, and differentiation, with IGF-1 signaling being essential for normal development and tissue maintenance

Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells

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As an important transcription factor, Nrf2 can not only regulate SLC7A11 transcription, but also up-regulate the expression of GSS and GCLC, which are key rate-limiting enzymes for GSH synthesis (Sun et al., 2016a