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Besides, the precise correlation between varied functional alterations in distinct brain regions affected by different neurodegenerative disorders and the corresponding modifications in brain vasculature and CBF within those areas remains elusive and not clearly defined

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GPX4 also plays a role in the development and maintenance of a variety of physiological functions, as global knockout of Gpx4 in mice causes embryonic lethality, whereas conditional Gpx4 knockout mice develop disorders in the endothelium, liver, brain, kidney, immune system, and hematopoietic system [57]

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