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At 24 months, 17.8 kg reduction from baseline (99.5 kg to 81.7 kg), BMI reduced by 5.5 kg/m (from 36.5 to 31.0 kg/m), maintaining 20.6% 3.2% weight loss, though 95% attrition limits clinical interpretability

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The FDA has approved Contrave for long-term weight management in adults who meet specific BMI requirements: A body mass index (BMI) of 30 kg/m or higher (obese), or A BMI of 27 kg/m or higher (overweight), plus at least one weight-related medical condition, such as high blood pressure, type 2 diabetes, or high cholesterol (dyslipidemia) Contrave is an ideal option for: Adults looking for mild to moderate weight loss People who also have depression or binge eating disorder, Contrave may help with mood and cravings Those who prefer taking a daily pill instead of weekly injections Only approved for use in adults (18 and older) If you prefer tablets over injections or do not require significant weight loss (above 10%), Contrave may be right for you