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Lipopolysaccharide-stimulated macrophage studies report reduced TNF- mRNA expression with effects maintained for 72-96 hours
Nevertheless, several investigators have studied BT by studying mesenteric lymph node tissue at the onset of laparotomy in patients without sepsis or trauma, which is cultured with viable bacteria categorized and compared to the existing intestinal luminal bacteria
The demonstrated activity of orally administered BPC-157 in gastrointestinal models confirms sufficient stability in gastric juice and resistance to complete enzymatic degradation during intestinal transit, at least for local mucosal effects if not systemic absorption
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