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The historical evidence also suggests potential benefits for people dealing with chronic pain, stress-related sleep disruption , or even substance withdrawal (though the latter should only be attempted under medical supervision)

Evidence suggests their presence indicates a distinct condition, or at least a more-clearly delineated subtype of IC/BPS

Furthermore, the lack of molecular indicators of angiogenesis or barrier compromise in this model raises compelling questions about the molecular thresholds and contextual signals required to initiate vascular changes during progressive neuronal loss (Thomsen et al