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Dose-escalation schedule: Start your patients at the 1.5 mg once-daily dose and follow the dose-escalation schedule

is the natural companion piece here

This means appetite suppression, slower digestion, and blood sugar effects all taper off slowly rather than stopping suddenly

Tesofensine is a triple monoamine reuptake inhibitor that works through the central nervous system by increasing levels of dopamine, norepinephrine, and serotonin