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Using TriNetX, a global database comprising over 120 million patients, we identified an overall cohort of 3747 patients with type 2 diabetes who received GLP-1 RA within 3 months of starting systemic therapy and identified 52,061 patients receiving metformin in the same timeframe as a control cohort

Clinical monitoring recommendations include: Baseline blood pressure measurement before initiating Zepbound Regular blood pressure and heart rate monitoring during dose titration (every 4-8 weeks) Assessment for orthostatic hypotension, particularly in patients taking antihypertensive medications Consideration of antihypertensive dose adjustments as weight loss progresses Monitoring of renal function and electrolytes in patients on diuretics or with significant gastrointestinal side effects Evaluation for medication-related adverse effects that might influence blood pressure (dehydration) Patients taking antihypertensive medications should be counseled about potential hypotension risk and instructed to report symptoms such as dizziness, lightheadedness, or syncope