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In a study of 16 patients with chronic CIPN who were in remission and no longer receiving chemotherapy, 30-minute application of an 8% capsaicin patch to the feet resulted in lower patient-reported levels of pain, touch-evoked pain, and cold-evoked pain, with overall significant pain relief (Anand 2019)

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Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling