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Treatment response may be affected by: the dose reached the length of treatment side effects and tolerability dietary intake physical activity sleep medical conditions current medicines adherence to treatment individual biology Semaglutide begins affecting appetite and blood-glucose regulation after treatment starts, but noticeable weight loss can take time

Many patients reduce or eliminate medications for related conditions as metabolic health improves throughout treatment

Patients with pre-existing respiratory conditions such as chronic obstructive pulmonary disease (COPD), asthma, or interstitial lung disease should inform their healthcare provider before starting Zepbound