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Cell membrane receptors transmit the change of pathological signals into epithelial cells to cause cascade reactions while integrin-based adhesions translate mechanical signals to affect actin aggregation and movement 52,53,54

Downstream of ROS accumulation, COX-2 and iNOS are key pro-inflammatory enzymes that amplify oxidative and immune-mediated damage

If it was left out for an extended period, sat in a hot car, or has an unknown temperature history, the conservative research decision is to discard it