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Although -synuclein is frequently implicated in PD pathogenesis, other proteins such as PTEN induced putative kinase 1 (PINK1), Parkin, DJ-1, leucine-rich repeat kinase 2 (LRRK2) have been strongly linked to familial forms of PD 6,7

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Recently, through the engagement of their respective receptors, studies have shown that GIP and GLP-1 have a synergistic effect on appetite and body weight when the peptides are combined in pharmacology [6, 8], but the exact mechanisms underlying the enhanced weight loss exhibited by GIPR/GLP-1R co-agonism are still to be elucidated

Mitochondrial dysfunction in pregnancy loss: a review