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Taken together with precedent from oncology, the overall evidence indicates that Erastin has clear therapeutic potential for EMS, provided drug delivery preferentially targets lesions while sparing healthy tissue

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Brain Energy Metabolism and Function Critically Depend on Glia-Neuron Lactate Dynamics Glia-neuron metabolic coupling in the CNS is primarily mediated by lactate shuttling through MCTs, and the expression of MCTs varies during development and under the influence of neurotransmitters and nutritional modifications, indicating its pivotal role in brain energy metabolism and functions (Pellerin et al., 1998b)

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