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As CDC Director Thomas Frieden put it in a JAMA editorial, Tobacco is, quite simply, in a league of its own in terms of the sheer numbers and varieties of ways it kills and maims people. We also continue to learn about the addictive power of nicotine, and the difficulty of breaking an addiction to it

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Supplementary material The Supplementary Material for this article can be found online at: SUPPLEMENTARY FIGURE 1 Treemap plots for GO Molecular functions

35 The Court countered this argument in its opinion, stating that "the FCLAA's comprehensive warnings, advertising restrictions, and pre-emption provision would make little sense if a State or locality could simply target and ban all cigarette advertising." 36 Accordingly, the Court concluded that the FCLAA preempted the regulations because it determined that "[t]he context in which Congress crafted the