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This phenomenon is known as induced systemic resistance (ISR) (Pieterse et al., 2014)

Rather than viewing this as personal failure, it reflects the biological reality that certain individuals benefit from extended or ongoing GLP-1 therapy as chronic disease managementsimilar to how some people need lifelong blood pressure or cholesterol medications

Heres how the experimental drug works and how it differs from Ozempic and Mounjaro

The key clinical question is not whether GLP-1 is universally safe in IBD, but rather: which individual patients are candidates, under what disease conditions, and with what monitoring safeguards