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Mechanism of Action in Laboratory Research Modulation of intracellular signaling pathways Enhancement of growth factor sensitivity in research models Regulation of gene expression patterns Influence on mitochondrial ATP production and energy metabolism Support of enzymatic activation and pathway mapping studies Primary Research Applications Metabolic Signaling Research: Investigating intracellular signaling cascades related to metabolic regulation

Red-blood-cell measurements did not show the same advantage

Findings from this study showed that ICV infusion of leptin improved cardiac function after myocardial infarction (MI) in rats, an effect that seems to be mediated by the brain melanocortin 4 receprtos (MC4R) since the cardioprotective effect of ICV leptin infusion is lost in MC4R knockout rats and infusion of MC4R agonist in the brain recaptulates leptins cardioprotective effect post-MI

Front Pharmacol 2021;11:589114.ArticlePubMedPMC 15