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Excessive Fe 2+ can react with lipid radicals and H 2 O 2 to produce a large amount of reactive oxygen species (ROS), which can damage membrane lipids, proteins, DNA, and other biological macromolecules, causing ferroptosis ( 3.2 Glutathione metabolism and ferroptosis GPX4 is an antioxidant enzyme found in mammalian cells

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Research has examined glutathione-S-transferase theta genotypes in relation to cyclophosphamide toxicity risk in dogs, illustrating that detox capacity is not identical across individuals (Ekena J, 2018)

Medical infrastructure is widely distributed across the country, with major centers in large metropolitan areas