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This combination is often explored in studies related to endocrine signaling rhythms, pulse modeling, metabolic readouts, and timing-dependent assay development

The incretin-related therapies dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) not only improve glycaemic control with a low risk of hypoglycaemia but can also have beneficial non-glycaemic effects such as avoidance of weight gain, reduced blood pressure and improvements in beta-cell function and cardiovascular risk biomarkers 1 3

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Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE