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Contact your GP or specialist if you experience any of the following: Unexplained or rapid weight gain or loss that is not related to dietary changes or a new medication Significant bloating or abdominal distension that is new or worsening this can occasionally indicate complications such as ovarian cysts or, rarely, other serious conditions, and should be assessed promptly Symptoms that may suggest a hormonal or thyroid issue, such as new or worsening fatigue, hair loss, mood changes, or irregular periods, alongside weight changes Side effects from current endometriosis medications that you believe are contributing to weight gain and are affecting your quality of life Interest in starting a prescription weight loss medication, to ensure it is appropriate and safe given your current treatment plan Seek urgent medical attention contact NHS 111 or attend your nearest A&E if you experience: Severe or sudden-onset abdominal or pelvic pain Fever alongside abdominal pain Persistent vomiting Severe pain with a positive pregnancy test or suspected ectopic pregnancy It is also worth seeking advice if weight concerns are affecting your mental health or your willingness to continue with prescribed endometriosis treatment

Summary of human clinical studies investigating gut microbiota composition in patients receiving GLP-1 receptor agonists

Among these, topical clonazepam and capsaicin have demonstrated clinical efficacy 17,18