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Description

The results indicated that excess fat storage is key to intestinal SKN-1 activation in the strains tested, irrespective of their lifespan phenotype

The role of the IGF-1 signaling cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle

Conclusion Our study reveals that the activation of NLRP3 inflammasome caused by mitophagy dysfunction plays an important role in cardiac hypertrophy induced by pressure overload, and semaglutide ameliorates the cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome