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These drugs helped lower blood sugar through a few specific mechanisms: Increased insulin secretion from the pancreas Reduced how much sugar the liver put into the bloodstream (via reducing glucagon) Slowed gastric emptying, which makes glucose appear slower in the blood stream

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Correlation matrix of eligibility criteria across populations

The field of ALS has advanced significantly over the last decade, with rapid progress in understanding the genetic architecture and the pathophysiological mechanisms of the disease, and in the development of robust, exploitable preclinical model systems