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doi: 10.15921/j.cnki.cyxb.2024.01.001 169 TanHChenJLiYLiYZhongYLiGet al

multiple Wound Repair and Regeneration publications) have documented GHK-Cu modulation of over 4,000 human genes upregulating approximately 2,000 and downregulating approximately 2,000 including major transcriptional regulators SP1, AP-1 (FOS/JUN), NRF2, and NF-B pathway components

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This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance