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In many of these studies, drug doses selected for evaluation are not necessarily related to clinical studies and plasma drug levels (a useful measure to compare whether preclinical studies have direct clinical relevance) are not reported and thus cannot be compared to those achievable in humans

Recent studies have suggested a potential role in aging and longevity

Target maintenance doses: Based on clinical data, 812 mg weekly will likely represent the effective therapeutic range for obesity management

61/780,565 filed March 13, 2013 which is incorporated herein by reference in its entirety as if fully set forth herein