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If vomiting or diarrhea persists beyond 24 hours or if unable to keep fluids down for 4-6 hours, medical evaluation is warranted to assess for dehydration and potential need for temporary medication adjustment or intravenous fluid replacement

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If you're also taking insulin or sulfonylureas, these may need adjustment to prevent hypoglycaemia when food intake is reduced

Rotating between multiple sites and varying the specific injection point within each region allows tissue recovery between injections and maintains consistent medication absorption throughout long-term therapy