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The mechanisms of the protective effect of quercetin could be the rebalancing of the antioxidant system and the modulation of renal biomarkers (Rahdar et al., 2021)

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MOTS-c is considered an exercise response factor, as exercise increases MOTS-c production, im-proves metabolism, and promotes skeletal muscle secretion of MOTS-c in experimental animals, perhaps via the induction of skeletal muscle MOTS-c expression by synergizing the lipocalin pathway with exercise 52

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