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Conversely, if genetic variants suggest faster metabolism, an optimized higher dose may deliver superior results

In addition, individual differences in the physiological requirements for testosterone often make it difficult for exogenous supplementation to meet the needs of individual patients [16]

Like sitagliptin, saxagliptin is also indicated as an adjunct to diet and exercise for the management of type 2 diabetes in adults

Further, T2DM remains one of the most significant risk factors not only for the development of MASLD but also for the progression of liver fibrosis and the occurrence of liverrelated complications, including HCC (Hosseinkhan et al., 2025