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42 Given the lack of response in glucose-tolerant patients, this study suggests that the mechanism by which GLP-1RAs improve psoriasis is indirect and mediated by glycemic control

Su accin principal se conoce como parte del efecto incretina , que explica por qu la glucosa oral produce una respuesta de insulina mayor que la glucosa administrada por va intravenosa, incluso cuando los niveles de glucosa en sangre son comparables

Therefore, drug delivery targeting the extracellular region of target receptors faces several insurmountable challenges, including (1) competitive interference from endogenous ligands or antibodies at the target and (2) pseudotarget or target loss caused by shedding or mutation of the extracellular region, which significantly inhibits drug efficacy and may pose safety concerns

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