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This multi-pronged approach is distinct from earlier-generation peptides that typically target one or two of these pathways

Among the experimentally characterized natively unfolded proteins included in that study (Uversky et al., 2000a), there were 7 proteins (7.8%), whose disordered status was confirmed by limited proteolysis, indicating the important role of this technique in establishing the IDP field

Symptoms can include swelling, hives, or difficulty breathing

The relative importance of particular residues has been approached by site-directed mutagenesis of single residues or groups of residues, development of specific phosphosite antibodies and, more recently, mass spectrometric analyses of phosphorylated residues