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According to the Food and Drug Administration (FDA), a product can contain as little as 50% synthetic nicotine and still be labeled as synthetic. Manufacturers say the tobacco-derived nicotine used in their products is purified or synthetic, but purifying nicotine derived from tobacco enough to reach medicinal levels is expensive

[14] Synthetic cannabis is suspected of being a potential contributory factor or direct cause of sudden death, due to the strain it can place on the cardiovascular system, or because of cannabinoid hyperemesis syndrome

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Environmental tobacco smoke (ETS) (also known as secondhand smoke) has been considered a health risk factor for a number of years 7