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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder

-Tocopherol is rapidly lost from the circulation, and more metabolites of -tocopherol are excreted in urine compared to -tocopherol, suggesting less -tocopherol is needed for use by the body (1)

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Researchers continue to study how these pathways relate to sexual arousal and related biological responses