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F.WakabayashiK.et al (1990)

Which is easy if you're dosing at bedtime, since you'll be asleep

We demonstrated that 1 h pretreatment of DEM attenuated NLRP3 inflammasome activation in microglial cells

As this occurs, oxidant accessibility and curvature would further exacerbate the situation, allowing more oxidation and therefore increased accessibility and curvature