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In the initial phase I clinical trial for MT-II conducted to evaluate the peptides safety and tanning potential, all subjects administered MT-II experienced statistically significant skin darkening [5]

25 A larger, double-blind RCT of 243 cancer patients receiving cisplatin or oxaliplatin and diagnosed with CIPN showed no significant difference in peripheral neuropathic symptoms between oral ALA 600 mg/day orally and placebo but further studies are needed to conclusively determine if ALA could benefit this subset of patients

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