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Stage 3: Hypothalamus and pituitary gland

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This secretion contains bufotenin, as well as a more potent relative of DMT called 5-MeO-DMT, known to induce distinct psychedelic experiences a fact well-known by those who have sought out the toad with the express purpose of licking it

This leads to physical and psychological tobacco withdrawal with symptoms such as poor concentration, insomnia, feelings of tension, restlessness, low mood and anxiety