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These include findings such as the pro-convulsant effects of a hitherto unidentified endogenous substance containing copper [112, 230], or depolarization-induced co-release of endogenous copper with the major inhibitory neurotransmitter -aminobutyric acid (GABA) in different experimental models of nerve terminals in vitro (synaptosomal fraction) and ex vivo ( median eminence ) [225]

However, other studies have revealed inhibition of the ERK pathway and reduced HB-EGF levels in PCOS patients (188)

In most healthy cells, this ratio is maintained in a highly reduced state between 30:1 and 100:1

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