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IL-1, together with Kupffer cell-derived TNF-, drives necroinflammation and hepatocyte death

This links ubiquitination and neddylation, indicating that neddylation affects the ubiquitination levels of target proteins affiliated with ubiquitin E3 ligases

Conversely, injection of 75 mg/kg/day of EGCG inhibits major hepatic antioxidant enzymes while significantly elevating Nrf2 expression and its target genes (231)