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The non-enzymatic system includes antioxidant molecules such as ascorbate (ASC), glutathione (GSH), tocopherols, proline, flavo- noids, carotenoids, phenolic compounds, cytochromes and polyamines (Ahmad et al

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However, prolonged reliance on glycolysis and subsequent oxidative stress can disrupt mitochondrial function, ultimately accelerating neurodegeneration

The potential for GLP-1RAs to provide atheroprotective and antioxidant benefits in MS patients with high disease activity is also emerging, potentially reducing vascular risk [269]