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Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo

Patients experiencing new or worsening dental problems while taking tirzepatide should report these concerns to their healthcare providers and consider reporting to the FDA MedWatch program, as documentation of such cases contributes to ongoing pharmacovigilance efforts

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GSK-3 down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress