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The bioefficacy of an oral glutathione supplement formulation is determined by its bioavailability and absorption of the active ingredient in the body

In line with this observation, the pre-administration of DSePA (2 mg/Kg bodyweight) for five consecutive days significantly improved the 30-day survival of mice against the lethal dose (-rays, 10 Gy) of WBI by preventing lipid peroxidation, DNA damage, and apoptosis in the radiosensitive organs like the spleen and small intestine [88, 89]

This epigenetic dimension connects the research to the broader field of metabolic epigenetics that researchers studying longevity peptides like epitalon also work in

doi: 10.3389/fimmu.2021.579140 29 BerghiNO