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L-methylfolate supports healthy homocysteine levels and endothelial function. IVF treatment : Women taking methylfolate with B12 had better supported fertility wellness compared to folic acid (60% vs 45% clinical pregnancy rate). People who do not tolerate folinic acid (possible MTHFS variantssee below)

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By collecting and analyzing changes in these metabolites, potential biomarkers associated with diseases can be identified, facilitating clinical diagnosis and disease stratification [44]