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Half-Life and Dose Adjustments The seven-day half-life affects how quickly dose changes take effect

Some patients feel full faster, eat smaller meals, or notice certain foods sit heavier than they used to

Even after treatment, this lower set point often persistsyou need fewer calories than someone who was never hypothyroid

One positive thing that typically stops when you discontinue the medication: the side effects, mainly gastrointestinal discomfort like nausea, says Matthew Hayes, a psychiatry professor at the Perelman School of Medicine at the University of Pennsylvania who studies neural signaling pathways in obesity